Serum oxytetracycline concentrations in African elephant (Loxodonta africana) calves after long-acting formulation injection.
نویسندگان
چکیده
Serum oxytetracycline pharmacokinetics were studied in 18 African elephant (Loxodonta africana) calves. Each elephant received separate injections of oxytetracycline at approximately 18 mg/kg i.m. and 8 mg/kg i.v. in a cross-over study. Blood samples were drawn at 0, 24, 48, 72, and 96 hr postinjection. An additional sample was drawn 110 hr before the animals were reinjected in the cross-over study and a final blood sample was drawn 48 hr after the second dose. No lameness or stiffness was observed following i.m. injections. Serum oxytetracycline concentrations >0.5 microg/ml were present 48 hr after initial dosing for all elephants (i.m., i.v., high or low dosage). Only elephants given the high i.m. dosage (18 mg/kg) maintained levels >0.5 microg/ml 72 hr postinjection. No significant difference in serum oxytetracycline concentration with time was observed between the groups given different i.v. dosages. These studies demonstrated that quantifiable serum oxytetracycline concentrations can be maintained in young African elephants with a low-dosage multidose i.m. regimen.
منابع مشابه
Loxodonta africana – African Elephant
Taxonomic notes: Preliminary genetic evidence suggests that there may be at least two species of African Elephant, namely the Savannah Elephant (Loxodonta africana) and the Forest Elephant (Loxodonta cyclotis) (Roca et al. 2001, 2005). A third species, the West African Elephant, has also been postulated. The IUCN SSC African Elephant Specialist Group currently accepts the single species proposa...
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Tissue concentrations of a long-acting oxytetracycline formulation after intramuscular administration in cattle.
The tissue distribution of a long-acting oxytetracycline formulation after intramuscular administration to calves at a dose rate of 20 mg/kg was studied. Oxytetracycline concentrations were determined in lung, bone marrow, mammary gland, uterus, uterine horn, ovary, liver, synovial fluid, joint tissue, kidney, spleen, brain, muscle, fat, urine, bile, saliva, ruminal content and serum. Observed ...
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ورودعنوان ژورنال:
- Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
دوره 31 1 شماره
صفحات -
تاریخ انتشار 2000